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Nov
7
2008

Doctors must first rule out other diagnoses when treating sleep disorders

The seventy million people in the United States suffer from sleep disorders. About 40 million of these suffer from acute sleep disorders, including circadian rhythm sleep disturbance.

Consider Dan, a 23-year old male complaining of . He can’t fall asleep at night and habitually arrives at work later than his employer’s 8 a.m. starting time. Does Dan have depression, situational insomnia, obstructive or a disturbance? Or does he just want to start work late?

"When someone claims he’s constantly late to work due to chronic sleep problems, a doctor must eliminate other possibilities first," said Dr. Skip Freedman, executive medical director at .

According to Freedman, circadian rhythm sleep disorder is a disturbance of a patient’s sleep-wake cycle.

Patients with circadian rhythm sleep disorders are unable to sleep or stay awake during work, school or social events. Circadian rhythm sleep disorders include jet lag, , irregular sleep wake phase, advanced sleep phase disorder (ASPD) and delayed sleep phase disorder (DSPD).

Rule out other disorders

"Doctors need to decide whether patients like Dan don’t like to go to work on time, are depressed, have situational insomnia or circadian rhythm sleep disturbance," said Freedman.

Once Dan’s doctor rules out using a depression questionnaire, he can refer Dan to a sleep specialist. Using a polysomnogram, also known as a sleep study, the specialist can check for other common sleep problems. Ruling them out, he can check Dan’s circadian clock markers next.

One technique is to measure Dan’s melatonin level, the hormone secreted by the pineal gland. Melatonin is the primary influencer of sleep and thus a sleep marker. During daylight, the gland produces less , because light suppresses melatonin production. As the light fades, the gland increases melatonin production to induce sleep.

Therapies for circadian disorders

Delayed sleep-phase syndrome and early sleep-phase syndrome are circadian rhythm disturbances treated by combining melatonin and phototherapy. Although phototherapy is standard of care for circadian disturbance, melatonin isn’t approved by the (), although it is available as a supplement in the United States.

In Dan’s case, the specialists discovered his melatonin levels were low during the times he’d normally sleep. This signaled a delayed sleep phase, and Dan took off two weeks from work to receive treatment.

Working back about an hour each day, the doctor’s treatment used melatonin to make Dan sleepy and exposed him to 2,500 lux of light for two to three hours. Lux is a unit of brightness emitted by candle to the eye one meter away.

The treatment pushed back Dan’s sleep-cycle pattern an hour a day for two weeks until he began falling to sleep at normal hours and could get to work on-time.

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/Health — Insomnia/doctors-rule-out-other-issues-treat-sleep-problems/2008-11-07.1422
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Interesting Apnea Statistics
~~ Apnea in United States ~~

As of May 2, 2009 at 9:47 p.m. (-0500) (ET), the U.S. population
was 306,340,710. Sleep researchers estimate approximately seven percent
of the population suffers from obstructive sleep apnea. Using that
estimate, there are potentially 21,443,850 apneics in the U.S.

~~ Apnea around the world ~~

As of May 2, 2009 at 9:47 p.m. (-0500) (ET), the world population
was 6,777,286,604. Sleep researchers estimate approximately seven percent
of the population suffers from obstructive sleep apnea. Using that
estimate, there are potentially 474,410,062 apneics in the world.