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	<title>Awake In America &#187; Narcolepsy</title>
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	<link>http://awakeinamerica.info</link>
	<description>Helping others sleep better every night!</description>
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		<title>Modafinil used to improve cognitive performance affects brain dopamine activity; suggests abuse &amp; dependence potential</title>
		<link>http://awakeinamerica.info/2009/top-news/modafinil-improves-cognition-may-cause-dependence/</link>
		<comments>http://awakeinamerica.info/2009/top-news/modafinil-improves-cognition-may-cause-dependence/#comments</comments>
		<pubDate>Wed, 18 Mar 2009 13:42:00 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Narcolepsy]]></category>
		<category><![CDATA[Top News]]></category>
		<category><![CDATA[ADHD]]></category>
		<category><![CDATA[amphetamine]]></category>
		<category><![CDATA[attention-deficit hyperactivity disorder]]></category>
		<category><![CDATA[central nervous system stimulant drugs]]></category>
		<category><![CDATA[Cephalon]]></category>
		<category><![CDATA[cognitive dysfunction]]></category>
		<category><![CDATA[dopamine]]></category>
		<category><![CDATA[enhance cognition]]></category>
		<category><![CDATA[enhance cognitive abilities]]></category>
		<category><![CDATA[euphoric effects]]></category>
		<category><![CDATA[increase dopamine]]></category>
		<category><![CDATA[methylphenidate]]></category>
		<category><![CDATA[modafinil]]></category>
		<category><![CDATA[neurotransmitter]]></category>
		<category><![CDATA[nucleus accumbens]]></category>
		<category><![CDATA[Provigil]]></category>
		<category><![CDATA[psychiatric disorders]]></category>
		<category><![CDATA[schizophrenia]]></category>
		<category><![CDATA[sleep disorders]]></category>

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		<description><![CDATA[Preliminary research in healthy men suggests that the narcolepsy drug modafinil, increasingly being used to enhance cognitive abilities, affects the activity of dopamine in the brain in a way that may create the potential for abuse and dependence, according to a study in JAMA.

Modafinil, a wake-promoting drug used to treat sleep disorders, may enhance cognition and is used off-label for the treatment of cognitive dysfunction in some psychiatric disorders, such as schizophrenia and attention-deficit/hyperactivity disorder (ADHD).<div class="addthis_toolbox addthis_default_style " addthis:url='http://awakeinamerica.info/2009/top-news/modafinil-improves-cognition-may-cause-dependence/' addthis:title='Modafinil used to improve cognitive performance affects brain dopamine activity; suggests abuse &#38; dependence potential '  ><a class="addthis_button_facebook_like" fb:like:layout="button_count"></a><a class="addthis_button_tweet"></a><a class="addthis_counter addthis_pill_style"></a></div>]]></description>
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		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Skin, core body temperatures affects narcoleptics&#8217; vigilance, sleepiness</title>
		<link>http://awakeinamerica.info/2008/top-news/temperature-affects-vigilance-sleepiness-in-narcoleptics-2/</link>
		<comments>http://awakeinamerica.info/2008/top-news/temperature-affects-vigilance-sleepiness-in-narcoleptics-2/#comments</comments>
		<pubDate>Mon, 05 May 2008 22:02:15 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Narcolepsy]]></category>
		<category><![CDATA[Top News]]></category>
		<category><![CDATA[brains]]></category>
		<category><![CDATA[cataplexy]]></category>
		<category><![CDATA[circadian rhythms]]></category>
		<category><![CDATA[core body temperature]]></category>
		<category><![CDATA[excessive daytime sleepiness]]></category>
		<category><![CDATA[fall asleep uncontrollably]]></category>
		<category><![CDATA[genetic links]]></category>
		<category><![CDATA[hallucinations]]></category>
		<category><![CDATA[Leiden University Medical Center]]></category>
		<category><![CDATA[Maintenance of Wakefulness Test]]></category>
		<category><![CDATA[narcoleptics]]></category>
		<category><![CDATA[Netherlands Institute for Neuroscience]]></category>
		<category><![CDATA[neurotransmitters]]></category>
		<category><![CDATA[Psychomotor Vigilance Task]]></category>
		<category><![CDATA[Rolf Fronczek]]></category>
		<category><![CDATA[skin temperature]]></category>
		<category><![CDATA[sleep paralysis]]></category>
		<category><![CDATA[sleep-wake rhythm]]></category>
		<category><![CDATA[sleepiness]]></category>
		<category><![CDATA[thermosuit]]></category>
		<category><![CDATA[vigilance]]></category>

		<guid isPermaLink="false">http://awakeinamerica.info/?p=88</guid>
		<description><![CDATA[In healthy people, both sleepiness and vigilance show a relationship with core body temperature and skin temperature. When core body temperature is high during the daytime, skin temperature is low, which translates into optimal vigilance.

Researchers noted during a recent study, though, that when core body temperature is low at night time, skin temperature is high, which correlates to optimal sleep. Among those suffering from narcolepsy, however, direct manipulations of their skin and core body temperatures affect their vigilance and sleepiness.<div class="addthis_toolbox addthis_default_style " addthis:url='http://awakeinamerica.info/2008/top-news/temperature-affects-vigilance-sleepiness-in-narcoleptics-2/' addthis:title='Skin, core body temperatures affects narcoleptics&#8217; vigilance, sleepiness '  ><a class="addthis_button_facebook_like" fb:like:layout="button_count"></a><a class="addthis_button_tweet"></a><a class="addthis_counter addthis_pill_style"></a></div>]]></description>
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		</item>
		<item>
		<title>Many narcoleptics with cataplexy have eating disorders</title>
		<link>http://awakeinamerica.info/2008/top-news/many-narcoleptics-with-cataplexy-have-eating-disorders/</link>
		<comments>http://awakeinamerica.info/2008/top-news/many-narcoleptics-with-cataplexy-have-eating-disorders/#comments</comments>
		<pubDate>Mon, 03 Mar 2008 19:02:50 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Narcolepsy]]></category>
		<category><![CDATA[Top News]]></category>
		<category><![CDATA[alertness]]></category>
		<category><![CDATA[binge eating]]></category>
		<category><![CDATA[body weight]]></category>
		<category><![CDATA[C]]></category>
		<category><![CDATA[cataplexy]]></category>
		<category><![CDATA[clinical eating disorders]]></category>
		<category><![CDATA[dreaming]]></category>
		<category><![CDATA[dreaming while awake]]></category>
		<category><![CDATA[eating disorders]]></category>
		<category><![CDATA[eating patterns]]></category>
		<category><![CDATA[food cravings]]></category>
		<category><![CDATA[Hal Droogleever Fortuyn]]></category>
		<category><![CDATA[hallucinations]]></category>
		<category><![CDATA[hypocretin]]></category>
		<category><![CDATA[hypocretin function]]></category>
		<category><![CDATA[hypothalamic disease]]></category>
		<category><![CDATA[N]]></category>
		<category><![CDATA[N/C]]></category>
		<category><![CDATA[narcolepsy with cataplexy]]></category>
		<category><![CDATA[obesity]]></category>
		<category><![CDATA[Radboud University Nijmegen Medical Center]]></category>
		<category><![CDATA[Sebastiaan Overeem]]></category>
		<category><![CDATA[sleep disorders]]></category>
		<category><![CDATA[sleep paralysis]]></category>
		<category><![CDATA[wakefulness]]></category>

		<guid isPermaLink="false">http://awakeinamerica.info/2008/home/many-narcoleptics-with-cataplexy-have-eating-disorders/</guid>
		<description><![CDATA[The majority of patients with narcolepsy/cataplexy experience a number of symptoms of eating disorders, with an irresistible craving for food and binge eating as the most prominent features, according to a study published in the March 1 issue of the journal Sleep.

Study authors Hal Droogleever Fortuyn, M.D., and Sebastiaan Overeem, M.D., of the Radboud University Nijmegen Medical Center in The Netherlands, focused on 60 patients who had been diagnosed with narcolepsy with cataplexy (N/C) who were recruited from specialized sleep centers and 120 healthy controls.<div class="addthis_toolbox addthis_default_style " addthis:url='http://awakeinamerica.info/2008/top-news/many-narcoleptics-with-cataplexy-have-eating-disorders/' addthis:title='Many narcoleptics with cataplexy have eating disorders '  ><a class="addthis_button_facebook_like" fb:like:layout="button_count"></a><a class="addthis_button_tweet"></a><a class="addthis_counter addthis_pill_style"></a></div>]]></description>
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		<slash:comments>0</slash:comments>
		</item>
		<item>
		<title>Mouse studies link feeding-behavior gene with narcolepsy</title>
		<link>http://awakeinamerica.info/1999/health/narcolepsy/mice-help-link-feeding-behavior-gene-to-narcolepsy/</link>
		<comments>http://awakeinamerica.info/1999/health/narcolepsy/mice-help-link-feeding-behavior-gene-to-narcolepsy/#comments</comments>
		<pubDate>Thu, 05 Aug 1999 15:04:00 +0000</pubDate>
		<dc:creator>admin</dc:creator>
				<category><![CDATA[Narcolepsy]]></category>
		<category><![CDATA[appetite stimulating hormone]]></category>
		<category><![CDATA[brain hormone]]></category>
		<category><![CDATA[brain proteins]]></category>
		<category><![CDATA[cataplexy]]></category>
		<category><![CDATA[circadian rhythms]]></category>
		<category><![CDATA[collapse and fall asleep]]></category>
		<category><![CDATA[deep sleep]]></category>
		<category><![CDATA[Dr. Christopher Sinton]]></category>
		<category><![CDATA[EEG]]></category>
		<category><![CDATA[EMG]]></category>
		<category><![CDATA[emotional triggers]]></category>
		<category><![CDATA[epileptic-like seizures]]></category>
		<category><![CDATA[feeding-behavior]]></category>
		<category><![CDATA[genes]]></category>
		<category><![CDATA[genetics]]></category>
		<category><![CDATA[irrepressibly sleepy]]></category>
		<category><![CDATA[journal Cell]]></category>
		<category><![CDATA[limp like a rag doll]]></category>
		<category><![CDATA[malfunctioning orexin gene]]></category>
		<category><![CDATA[Masashi Yanagisawa]]></category>
		<category><![CDATA[mice]]></category>
		<category><![CDATA[mice are nocturnal]]></category>
		<category><![CDATA[mouse]]></category>
		<category><![CDATA[narcolepsy in humans]]></category>
		<category><![CDATA[narcolepsy is familial]]></category>
		<category><![CDATA[narcoleptic Doberman pinschers]]></category>
		<category><![CDATA[narcoleptic episodes]]></category>
		<category><![CDATA[narcoleptic patients]]></category>
		<category><![CDATA[neuropeptide]]></category>
		<category><![CDATA[nocturnal surveillance]]></category>
		<category><![CDATA[orexins]]></category>
		<category><![CDATA[orexis]]></category>
		<category><![CDATA[origins of narcoleptics]]></category>
		<category><![CDATA[quickly falls asleep]]></category>
		<category><![CDATA[rapid eye movement]]></category>
		<category><![CDATA[receptors]]></category>
		<category><![CDATA[REM]]></category>
		<category><![CDATA[Richard Chemelli]]></category>
		<category><![CDATA[sense of paralysis]]></category>
		<category><![CDATA[sleep disorders]]></category>
		<category><![CDATA[sleep-wake cycle]]></category>
		<category><![CDATA[Southwestern Medical Center]]></category>
		<category><![CDATA[Stanford University]]></category>
		<category><![CDATA[University of Texas]]></category>
		<category><![CDATA[vivid dreams]]></category>

		<guid isPermaLink="false">http://awakeinamerica.info/1999/health/narcolepsy/mice-help-link-feeding-behavior-gene-to-narcolepsy/</guid>
		<description><![CDATA[Researchers who had bred a group of mice in hopes of learning more about a brain hormone that stimulates appetite got a bit of a surprise when they saw that the rodents would suddenly collapse and fall fast asleep with no provocation. As a result, Howard Hughes Medical Institute investigator Masashi Yanagisawa and colleagues at the University of Texas' Southwestern Medical Center in Dallas have an exciting new lead into the genesis of sleep and the origins of narcolepsy, a severe sleep disorder in humans.

In 1998, Yanagisawa discovered the orexins, small brain proteins and their receptors that regulate feeding behavior in mice. To probe the role that orexins play in regulating appetite, Yanagisawa and his colleagues developed a strain of knockout mice whose orexin genes do not function properly.<div class="addthis_toolbox addthis_default_style " addthis:url='http://awakeinamerica.info/1999/health/narcolepsy/mice-help-link-feeding-behavior-gene-to-narcolepsy/' addthis:title='Mouse studies link feeding-behavior gene with narcolepsy '  ><a class="addthis_button_facebook_like" fb:like:layout="button_count"></a><a class="addthis_button_tweet"></a><a class="addthis_counter addthis_pill_style"></a></div>]]></description>
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