A research collaboration led by biologists and neuroscientists at the University of Pennsylvania has found a molecular pathway in the brain that is the cause of cognitive impairment due to sleep deprivation.
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cognitive deficits
Oct
30
2009
University of Penn researchers find way to reverse cognitive impairment caused by sleep deprivation
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Just one night without sleep can increase the amount of the chemical dopamine in the human brain, according to new imaging research in the August 20 issue of the Journal of Neuroscience. Because drugs that increase dopamine, like amphetamines, promote wakefulness, the findings offer a potential mechanism explaining how the brain helps people stay awake despite the urge to sleep.
However, the study also shows that the increase in dopamine cannot compensate for the cognitive deficits caused by sleep deprivation.
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People with obstructive sleep apnea have been reported to have increased markers of oxidative stress and exhibit architectural changes in their brain tissue in areas involved in learning and memory. Chronic intermittent hypoxia in rats produce similar neurological deficit patterns.
“Obstructive sleep apnea has been increasingly recognized as a serious and frequent health condition with potential long-term morbidities that include learning and psychological disabilities,” wrote David Gozal, M.D., professor and director of Kosair Children’s Hospital Research Institute at the University of Louisville, lead author of the article.
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